equinoxe
Topics: 15
Posts: 77
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About 5% of individuals in a particular population are known to carry a recessive gene for poliodystrophy. an inherited disorder
characterized by recurrent seizures and dementia with onset in early childhood. A 32-year-old healthy woman who had a brother with this disorder seeks genetic counseling. The patient's husband, an only child, does not know if his family has a history of the disorder. What is the probability that the patient is a carrier of poliodystrophy?
A) 1/20
B) 1/10
C)3/8
D)2/3
E) 3/4
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| equinoxe
Topics: 15
Posts: 77
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help... I can't understand how o solve this q... there's a similar NBME 4 similar q. please help and explain. Thank you...
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A couple seeks genetic counseling following the recent diagnosis of cystic fibrosis in their youngest child. Their two older children are healthy and have normal sweat chloride test results. Which of the following is the likelihood that each of the unaffected children is a carrier of cystic fibrosis?
A) 1 in 2
B) 1 in 3
C) 1 in 4
D) 2 in 3
E) 3 in 4
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| drbin
Forum Guru
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B?
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| drbin
Forum Guru
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Sorry A ie 1/20
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| drbin
Forum Guru
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Posts: 535
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for 2nd Q is it D 2/3?
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| macTT
Forum Senior
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Drbin,
I agree with you,
I think for the 2nd question is D 2/3. The first is is 1/20 is it because it is an AR disorder. I would have chosen B if it was by chance alone.
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| Ancylostoma
Forum Guru
Topics: 42
Posts: 642
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I want to know why the first answer is A. It looks to me that you guys got the answer wrong. Her brother had the disease that means at the very least that both of there parents have to be carriers. Thats the most common pairing. The answer for the first one is 2/3. D
I love it when someone tries to be cocky, hehe dr. bin (you should always be extremely careful when you use the winking smiley)
Edited by Ancylostoma on 01/04/07 - 10:45 PM
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| equinoxe
Topics: 15
Posts: 77
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for both questions the answer is D. 2/3 will come back in a sec with expl directoly from the source.
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| aim
Forum Junior
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pl somebody explain 1st ans
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| jabialaa
Forum Newbie
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plz i think the answer must be 2/4 for the first question
as the disease start at childhood ..... this mean that the parents are healthy .... so must both of them be carrier to the gene ...
so
Aa x Aa
>>>>>>>>>>>>>>>>>> AA 1/4 Aa 2/4 aa 1/4
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| borrelia
Forum Newbie
Topics: 1
Posts: 22
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It is definitely D in both.... the answer is in kaplan notes...
so as you said before, aa is 1/4 (as it is AR the small case is the allele with the disease, and she does NOT have the trait) so that leaves you with 3 possibilities AA, Aa, Aa, AA is not even carrier, so 2 out of 3... are her possibilities to be carrier.
am i right? 
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| lq2006
Forum Elite
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Posts: 382
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2/3 for both
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