sataleees
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what is the mechanism by which alcohlism can cause hyperlipidemia??
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| sataleees
Forum Newbie
Topics: 4
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any body?
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| Leopard
Forum Guru
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Alcohol causes excessive production of NADH through its metabolism
Alcohol ----------> acetaldehyde -----------> acetate
Both of these reactions produce NADH .NADH/NAD ratio is highly increased
Triglycerided are formed from
- Glycerole 3-phosphate
Fatty acides
Enzyme responsible is Fatty Acyl Co -A transferase
With ethanol ingestion all of them are increased in the liver
GLYCEROL 3 - PHOSPHATE
It is formed from Glycolytic intermediate DHAP
DHAP -----------(NADH) -------------> Glycerol 3-phosphate
FATTY ACIDS
These are from
- Denovo sysnthesis in the liver from acetate produced from Ethanol
Lipolytic effect on the adipose tissue through the action of epinephrine thus FA goin to Liver and
From the diat
These Fatty acids are not metabolized throught beta oxidation due to high NADH/NAD ratio.
FATTY ACYLE Co-A TRANSFERASE
This is Endoplasmic enzyme and many endoplasmic enzymes are induced by Ethanol chronic consumption
Consequently thre is excessive production of Triglycerides which are packed in VLDL and released into Blood.-----------> type IV Hyperlipidemia
Best of luck
Edited by Leopard on 11/17/06 - 09:46 AM. Reason: correction
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| kashdoc21
Forum Senior
Topics: 52
Posts: 127
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this was a good blast from goljan ..keep it up ..
n thank you
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| sataleees
Forum Newbie
Topics: 4
Posts: 32
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THANX ALOT
good luck all
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