Allison
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A 10-month-old boy with hemoglobin SS disease is brought to the emergency department by his parents because of severe pain in his feet for 2 hours. He appears acutely ill and is crying. Vital signs are normal except for a pulse of 160/min. Physical examination shows splenomegaly and edematous, tender feet. Laboratory studies show a hemoglobin concentration of 7 g/dL and a reticulocyte count of 12%. A peripheral blood smear shows target cells, poikilocytes, and sickled erythrocytes. Which of the following processes most likely caused the sickled erythrocytes in this patient?
A) Decreased interaction of hemoglobin S with spectrin upon deoxygenation
B) Inability of abnormal β chains to form tetramers upon deoxygenation
C) Inability of abnormal β chains to form tetramers upon oxygenation
D) Increased interaction of hemoglobin S with spectrin upon oxygenation
E) Spontaneous polymerization of hemoglobin S upon deoxygenation
F) Spontaneous polymerization of hemoglobin S upon oxygenation
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| ssrpk
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E) Spontaneous polymerization of hemoglobin S upon deoxygenation
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