ManuNastai
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3. A 68-year-old woman has breast cancer that is metastatic to the axillary lymph nodes. The primary tumor is excised and chemotherapy, including cyclophosphamide and tamoxifen, is started. Which of the following mechanisms best explains the likely beneficial effect of tamoxifen in this patient?
A) Competition with cytoplasmic estrogen receptors
B) Enhancement of cyclophosphamide cytotoxic effect therapy
C) Inhibition of residual estrogen synthesis by the ovaries and adrenal glands
D) Retardation of tumor growth by its androgenic activity
E) Stimulation of membrane-bound progestin receptors
19. A 23-year-old woman with a history of asthma comes to the physician's office because she has had progressive wheezing over the past 2 days. Which of the following drugs is most likely to induce bronchodilation in this patient by activation of adenylyl cyclase?
A ) Albuterol
B ) Beclomethasone dipropionate
C ) Cromolyn sodium
D ) Ipratropium bromide
E ) Theophylline
27. A 2-year-old girl is brought to the emergency department 90 minutes after ingesting a drug from her mother's purse. On arrival, the child is sedated; respirations and blood pressure are normal. Which of the following drugs is most likely to reverse the sedation?
A ) Acetylcysteine
B ) Amyl nitrate
C ) Apomorphine
D ) Atropine
E ) Flumazenil
F ) Haloperidol
G ) Naloxone
30. A 39-year-old woman with rheumatoid arthritis develops proteinuria after treatment with penicillamine. Examination of tissue obtained on renal biopsy shows diffuse fine granular deposits of IgG and C3 in the glomerular basement membrane. The most likely diagnosis is
A) Focal segmental sclerosis
B) Goodpasture's syndrome
C) IgA nephropathy
D) Membranous glomerulonephritis
E) Minimal change disease
39. A clone of cancer cells is resistant to vincristine, doxorubicin, and dactinomycin but not to methotrexate and various alkylating agents. The mechanism of resistance is most likely to involve
A ) Absence of superoxide dismutase
B ) Altered DNA polymerase
C ) Enhanced drug transport out of the cell
D ) Inability to form polyglutamates
E ) Increased DNase
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"Love is the only inflamation of the heart that drains in the vagina" (translation after Dr Petre Florescu, Professor of Pathology, UMF "Iuliu Hatieganu", Cluj Napoca
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| NE
Forum Guru
Topics: 53
Posts: 504
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3- tamoxifen is a selective estrogen receptor modulator
19- albuterol -increases of cAMP means receptor cupled with Gs= beta 2 in this case
27- benzodiaz. intox- flumazenil
30 - D
39- I gues is B because all are drugs with action on DNA.
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| yasmeen
Forum Guru
Topics: 67
Posts: 936
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39 C REST AGREE WPTH NE
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| ManuNastai
Transilvanian..
Topics: 55
Posts: 838
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thanks.. 39 is indeed a stupid Q that was intensely discussed before and C seemed to be the correct answer. I hope I won't get any Qs like this one on my exam..
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"Love is the only inflamation of the heart that drains in the vagina" (translation after Dr Petre Florescu, Professor of Pathology, UMF "Iuliu Hatieganu", Cluj Napoca
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| NE
Forum Guru
Topics: 53
Posts: 504
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yes, you are right!I checked and the increased efflux of the drug from tumor cells via membrane drug transport is the answer.
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| qumsieh
Forum Newbie
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3) is A
19) A
27)C
30)D
39) is C folks !
Ross University Graduate
Massachusetts General Hospital
Harvard College
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| Yulik08
Forum Newbie
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why 27 is C? isn`t it E Flumazenil?
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| taipei817
Forum Newbie
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apomorphine is for dyskineisa that occurs with parkinson treatment, this isnt the answer, Harvard.
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