ManuNastai
Transilvanian..
Topics: 55
Posts: 838
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4. A 56-year-old man who has colon cancer is being treated with 5-fluorouracil. Which of the following is the mechanism of the antineoplastic action of this drug?
A) Binding free dihydrofolate
B) Inhibiting carbamoyl phosphate synthetase I
C) Inhibiting ribonucleotide reductase activity
D) Inhibiting thymidylate synthetase activity
Answer: D)
8. A 53-year-old woman comes to the clinic because of a 1-week history of pain and burning on urination. She is homeless and has a poor diet. The physician gives her enough trimethoprim-sulfamethoxazole to last 2 weeks. Because of her inadequate diet, she is at increased risk for which of the following adverse effects of this drug?
A) Cardiomyopathy
B) Megaloblastic anemia
C) Ototoxicity
D) Seizures
E) Systemic lupus erythematosus
13. An experimental drug is administered to a human subject with moderately severe congestive heart failure. Within minutes of intravenous administration, there is a measurable decrease in cardiac preload and cardiac afterload, and an increase in glomerular filtration rate. The effects of the drug are most similar to those produced by which of the following?
A) ADH (vasopressin)
B) Aldosterone
C) Angiotensin II
D) Atrial natriuretic peptide
E) Insulin
F) Norepinephrine
15. An obese 82-year-old woman with a 20-year history of type 2 diabetes mellitus has been taking glyburide orally for the past 5 years. Metformin is added to her regimen. Because she is taking metformin, she is at increased risk for which of the following?
A) Diabetic ketoacidosis
B) Lactic acidosis
C) Metabolic alkalosis
D) Renal tubular acidosis
E) Respiratory alkalosis
21. A 38-year-old woman undergoes surgical repair of a hip fracture. She has been treated for the past 20 years with high doses of inhaled and oral medications for severe asthma. During surgical repair, severe osteoporosis is noted. Long-term administration of which of the following drugs is most likely to have caused the osteoporosis?
A) Albuterol
B) Cromolyn sodium
C) Ipratropium
D) Prednisone
E) Theophylline
___________________
"Love is the only inflamation of the heart that drains in the vagina" (translation after Dr Petre Florescu, Professor of Pathology, UMF "Iuliu Hatieganu", Cluj Napoca
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| ManuNastai
Transilvanian..
Topics: 55
Posts: 838
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my answers:
4. D
8. B
13. D
15. ??
21. D
in an older discussion the answer to 15 was given B. could someone, please, explai why?
___________________
"Love is the only inflamation of the heart that drains in the vagina" (translation after Dr Petre Florescu, Professor of Pathology, UMF "Iuliu Hatieganu", Cluj Napoca
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| NE
Forum Guru
Topics: 53
Posts: 504
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The most dangerous side effect of metformin is lactic acidosis (1/30000, fatal in 50% of cases). The symptoms of lactic acidosis are weakness, trouble breathing, abnormal heartbeats, unusual muscle pain, stomach discomfort, light-headedness and feeling cold.
Patients at risk for lactic acidosis:
RENAL FAILURE
HEPATIC FAILURE
congestive heart failure
severe acute illnesses
and dehydration
Attached Files:
ca in cell.jpg (5 KB, 5 downloads)
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| NE
Forum Guru
Topics: 53
Posts: 504
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SORRY, I don't know how this picture getting there!
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| fox
Forum Guru
Topics: 70
Posts: 727
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Yes lactic acidosis is the answer.....metformin is a biguanide.
Rest of ur answers are bang on target.....bull's eye!
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Aim High
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| ManuNastai
Transilvanian..
Topics: 55
Posts: 838
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to attach a fullsize picture type "img", put the link to the picture and then type "/img". if there are any other commands that you don't know and u see other users using them, click on quote button and you'll see how they did (that's my trick)
PS: the img and /img must be between large brackets
___________________
"Love is the only inflamation of the heart that drains in the vagina" (translation after Dr Petre Florescu, Professor of Pathology, UMF "Iuliu Hatieganu", Cluj Napoca
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