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A 32-year-old man has had malaise, a low-grade fever, and a 4.5-kg (10-lb) weight loss over the past 3 months. He has unilateral cervical lymphadenopathy. Laboratory studies show:


Hemoglobin 11 g/dL
Hematocrit 33%
Mean corpuscular volume 80 μm3
Reticulocyte count 0.5%
Serum iron 25 μg/dL
Total iron-binding capacity 150 μg/dL (N=250–460)

Examination of tissue obtained on biopsy of a lymph node shows Hodgkin's disease, nodular sclerosing type. The most likely cause of the anemia is
A ) abnormal utilization of iron
B ) extravascular hemolysis
C ) folate deficiency
D ) iron deficiency
E ) marrow aplasia







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