fox
Forum Guru
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Please explain what they r asking. I didnt get the question itself....let alone the answer.
A 3-year-old boy has a mutation in the calcium receptors on cell surfaces of his parathyroid gland and on the basolateral (blood) side of the thick ascending limb of the loop of Henle. Which of the following patterns is expected with a mutation that leads to activation of this receptor in the absence of binding of its ligand, calcium?
Ca2+ Serum PTH Urine Ca2+
a) Hypercalcemia high high
b) Hypercalcemia high low
c) Hypercalcemia low high
d) Hypercalcemia low low
e) Hypocalcemia high high
f) Hypocalcemia high low
g) Hypocalcemia low high
h) Hypocalcemia low low
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| ManuNastai
Transilvanian..
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I know it was discussed before.. but don't know what was the general consensus..
I believe h
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| ssrpk
Forum Fanatic
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well, Ca++ sends the signal to parathyroid to decrease its secretion of PTH...so if the receptor is constitutively activated it wud keep the PTH levels low despite low Ca++!
thus the answer shud be G) Ca++ will increase in the urine
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| ManuNastai
Transilvanian..
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yes, but isn't Ca++ reabsorbed in the TAL of Henle's loop? So, stimulating the receptors wouldn't stimulate Ca reabsorbtion?
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"Love is the only inflamation of the heart that drains in the vagina" (translation after Dr Petre Florescu, Professor of Pathology, UMF "Iuliu Hatieganu", Cluj Napoca
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| myba
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