linaorvos
Forum Elite
Topics: 47
Posts: 258
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original 5' ACT-GAT-TGC-GTT 3'
sequence is mutated by insertion of single nucleotide A in 2 codon,
becomes 5' ACT-GAA-TTG-CGT 3'
Which of the following consequence of this mutation?
a.althered cell cycle checkpoint
b.decrease the rate of transcription
c.protein trucation
d.single AA substitution
anyone..please!
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| vallia
Forum Guru
Topics: 98
Posts: 889
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well, i just read the mutations again and still couldn't figure it. anyone?
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| linaorvos
Forum Elite
Topics: 47
Posts: 258
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i was guessing c, but the result showed i did poorly in biochem....so.....
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| NE
Forum Guru
Topics: 53
Posts: 504
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It is C- frameshift mutation which will change the protein synthesized and the new protein will be truncated because has different AA.
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| kashdoc21
Forum Senior
Topics: 52
Posts: 127
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frameshift mutation = insertion of a nucleotide = usually results in loss of fn / truncated protien / altered protein synth
i think it is an incompl chioces suggested in the Q , please can anyone confirm this ans
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| hari.v
Forum Newbie
Topics: 0
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i was under the impression that any nucleotide insertion in the 3rd position of codon wont have any significant impact on the protein transcription.....more like a silent mutation. with the given choices would B be a possible option.
any thoughts people??
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| drfax
Forum Elite
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C
frameshift mutation causes protien truncation
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| girl^interrupted
Forum Elite
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GAT is aspartate
GAA is glutamic acid,
So all the amino acids are affected down the line..Hence its a frameshift mutation n will cause protein truncation
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| sataleees
Forum Newbie
Topics: 4
Posts: 32
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It is C..
completely different protein althogh the second aa is the same the last 2 are different.. so it will cause protein truncation...
i think so
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