dxtxpx
Forum Guru
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Hi in Lippincott 2nd ed; page 77, they have listed acebutolol first as selective beta 1 antagonist & then in next paragraph as antagonists with partial agonist describing it as not a pure blocker but ability to stimulate both beta1 and beta2 receptors with ISA
please can anyone make this clear for me :?
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| mjl1717
Forum Hero
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low doses its B1 blocker
at high doses it has some B2 blocking affects
It has some mild B1 and B2 sympathomimetic activity(not as strong as isoproterenol)
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| dxtxpx
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thanks
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| krsma
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Acebutolol is a B1 agonist, but it's also a partial agonist at the beta receptor meaning that it slightly stimulates at the beta receptor. This property ensures that some degree of stimulation of beta-receptors is maintained. As I remember reading, under conditions of rest this tends to balance the negative chronotropic and negative inotropic effects.
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