Charcot wrote:
On an test I had a Q asking where Renin is manufactured.I can remeber that one of the choices was liver and this what I ticked.
Is actually renin manufactured in the liver if not where is this done?
I racall that renin is an enzyme secreted by the juxtaglomerular cell in the JG apparatus to regulate blood pressure.
Renin is produced in the juxtaglomerular apparatus, which is actually found in the kidney...
It indirectly causes increased ion reabsorption, which causes increases water absorption, which causes increase in blood pressure... It is a mechanism the body uses to maintain blood pressure...
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| po
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Renin activates the renin-angiotensin system by cleaving angiotensinogen, produced in the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE, the angiotensin-converting enzyme. This is a membrane-bound enzyme present on the surface of the vascular endothelium of blood vessels throughout the body. The lung is the primary organ responsible for angiotensin II conversion, due to the large endothelial surface area of the many capillaries used in gas exchange. Angiotensin II then constricts blood vessels, increases the secretion of ADH and aldosterone, and stimulates the hypothalamus to activate the thirst reflex, leading to increased blood pressure.
Renin is secreted from juxtaglomerular cells, which are activated via signalling (the release of prostaglandins) from the macula densa, which respond to the rate of fluid flow through the distal tubule. A drop in the rate of flow past the macula densa implies a drop in renal filtration pressure. Renin's primary function is therefore to eventually cause an increase in blood pressure, leading to restoration of perfusion pressure in the kidneys.
from wikepedia
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| po
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An over-active renin-angiotension system leads to vasoconstriction and retention of sodium and water. These effects lead to hypertension. Therefore, renin inhibitors can be used for the treatment of hypertension.
Novartis' Rasilez (aliskiren) is a first-in-class oral renin inhibitor undergoing Phase III clinical trials as of 2006. Rasilez, an octanamide, is the first known representative of a new class of completely non-peptide, low-molecular weight, orally active transition-state renin inhibitors. Designed through the use of molecular modeling techniques, it is a potent and specific in vitro inhibitor of human renin (IC50 in the low nanomolar range), with a plasma half-life of ≈24 hours. Rasilez has good water solubility and low lipophilicity and is resistant to biodegradation by peptidases in the intestine, blood circulation, and the liver.
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| kingusmle
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renin is an enzyme that is secreted frm juxtaglomerular cells of the kidney
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