Renegade
Forum Elite
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I was researching nonsteroid anti-inflammatory drugs on Harrison's when in page 681 (Hemophilia A) I read "Avoid the use of aspirin or aspirin-containing drugs, which impair platelet function and may cause severe hemorrhage. Cyclooxygenase inhibitors can be used, as they do not impair platelet function." I think they meant COX-2, right? For instance, I thought they considered inhibition a different mechanism from inactivation ; however, a few pages ahead when describing aspirin itself (page 687) "COX inhibition leads to the prevention of thromboxane A2 synthesis and impairment of platelet secretion and aggregation."
So... is there something I'm missing here? I just hope it's not something very obvious. 
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«The desire to take medicine is perhaps the greatest feature which distinguishes man from animals.» W. Osler
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| Leopard
Forum Guru
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Dear
The case is clear
All NSAIDS are COX inhibitors including Aspirin
Aspirin inhibits COX by acetylation ,so it is permanant.Platelets cannot regenerate new COX (protien) because they lack Nuclei and ribosomes.On the other hand other NSAIDS cause reversible inhibition of COX enzyme ,so these are safer.
Best of luck
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| Renegade
Forum Elite
Topics: 18
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Exactly as I though.
The case might be clear, but I wouldn't consider that couple of sentences clear at all. They don't seem very right to me. Oh well, thank you for your answer.
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«The desire to take medicine is perhaps the greatest feature which distinguishes man from animals.» W. Osler
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