drfax
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A 28 y/o previously healthy man has noted increasing fatigue for the past 6 months and formation of bruises after minimal trauma. Over the past 2 days, he has developed a cough. On physical exam, his temp. is 38.9C, and he has diffuse rales in both lungs. He has no hepatosplenomegaly and no lymphadenopathy. Lab. findings include a Sputum culture positive for Strept. pneumoniae, hemoglobin of 7.2 g/dL, hematocrit 21.7% platelet count 23,400/cc, WBC count 1310/cc, PT 13 sec., PTT 28 sec, and total bilirubin 1.0mg/dL. The ANA test result is negative. Which of the following is most likely explanation for these findings ?
A. Hemolysis of antibody-coated cells
B.Hyperslenism
C.Increased susceptibility of lysis by complement
D.Metastatic adenocarcinoma
E.Nuclear maturation defects due to impaired DNA synthesis
F. Stem cell defect
G. Varicella-zoster virus infection
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| Leopard
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F
The patient has stem cell defect (aplastic anemia)
Best of luck
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| drfax
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Why not A ?
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| ManuNastai
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'cause bilirubin is normal
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| drfax
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thnx
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