ola_godin
Forum Newbie
Topics: 3
Posts: 7
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degradation of extracellular matrix is accomplished by which?
a)lysyl oxidase
b)plasmin
c)plasminogen
d)serpins
e)TIMPS
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| MD_toronto
Forum Junior
Topics: 2
Posts: 27
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b. plasmin
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| yasmeen
Forum Guru
Topics: 67
Posts: 936
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e
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| fox
Forum Guru
Topics: 70
Posts: 727
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watz that TIMPS?
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Aim High
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| spjokes
Forum Senior
Topics: 3
Posts: 88
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B) Plasmin
plasminogen activator (uPA/ tPA) converts plasminogen to plasmin which helps in ECM degradation.
(this is a crucial step in tumor invasion)
http://www.eurekah.com/chapter/162
for the sake of completion.....
TIMPS- Tissue inhibitor of metallo proteinases
(inhibit the degradation of ECM)
SERPIN-
any of a superfamily of inhibitors of serine endopeptidase (serine protease) found in plasma and tissues, all being strongly homologous single-chain glycoproteins. Among their targets are serine endopeptidases involved in coagulation, complement activation, fibrinolysis, inflammation, and tissue remodeling. The serpins include alpha1-antitrypsin, antithrombin III, α2-antiplasmin, C1 inhibitor, heparin cofactor II, and plasminogen activator inhibitor 1 (PAI-1). Called also serine protease or proteinase inhibitor.
lysyl oxidase
an enzyme of the oxidoreductase class that catalyzes the oxidative deamination of lysine and hydroxylysine residues to the corresponding aldehydes, a step in the formation of covalent crosslinks in collagens and elastins. The reaction requires pyridoxal phosphate and Cu2+; the deficiency of enzyme activity and attendant physiological consequences occurring in Ehlers-Danlos syndrome, type IX (X-linked cutis laxa) and Menkes' syndrome appear to be secondary to deficiencies in copper metabolism or transport.
lysyl hydroxylase
is an enzyme of the oxidoreductase class that catalyzes the hydroxylation of specific lysine residues in nascent procollagen chains; the hydroxylysine residues act as sites of attachment for disaccharide prosthetic groups and are involved in the formation of strong interchain crosslinks in collagen. The enzyme requires Fe2+, ascorbate, and α-ketoglutarate for activity. Deficiency of enzyme activity, an autosomal recessive trait, results in Ehlers-Danlos syndrome, type VI.
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