Musuq
Forum Guru
Topics: 103
Posts: 425
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A 64-year-old woman comes to the physician's office because of gradually worsening abdominal cramps, nausea, diarrhea, flushing of the skin, and heart palpitations. Twenty-four hour urinary 5-hydroxyindoleacetic acid excretion is increased. The most likely cause of these findings is a neoplasm originating in which of the following structures? <?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" />
A. Adrenal gland
B. Esophagus
C. Kidney
D. Small intestine
E. Spleen
F. Thyroid
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| me007
Forum Guru
Topics: 72
Posts: 803
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A serotonin analysis is most frequently performed for the diagnosis of carcinoid tumors of the enterochromaffin (Kultschitzsky) cells of the small intestine. These tumor cells release large amounts of serotonin, which can produce the clinical syndrome of flushing, diarrhea, and right-sided heart failure. The most frequently used diagnostic test for carcinoid tumors is 5-HIAA, the final metabolite of serotonin. Diagnose carcinoid tumors and syndrome; values >25 mg/24 hours (higher if the patient has malabsorption) are strong evidence for carcinoid.
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| fongch
Forum Elite
Topics: 71
Posts: 316
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So the answer is C, right?
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| kashdoc21
Forum Senior
Topics: 52
Posts: 127
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Ans : A /D ?
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| dreamer
Forum Elite
Topics: 52
Posts: 152
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here is what fa says ,page 257: carcinoid syndrome: rare syndrome caused by carcinoid tumors,especially metastatic small bowel tumors, which serecte high levels of serotonin(5HT).not seen if tumor is limited to GI tract(5HT undergoes first pass metabolism in liver)
could someone clear my confused? metastatic small bowel tumors, it means the primary tumor place is small bowel , or it is somewhere else metastitic to small bowel??
but i think it is d .
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you may say i am a dreamer,but i am not the only one...........
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| usmle4me
Forum Elite
Topics: 6
Posts: 283
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D
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| fongch
Forum Elite
Topics: 71
Posts: 316
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Sorry I mean D
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| ManuNastai
Transilvanian..
Topics: 55
Posts: 838
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D
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"Love is the only inflamation of the heart that drains in the vagina" (translation after Dr Petre Florescu, Professor of Pathology, UMF "Iuliu Hatieganu", Cluj Napoca
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