recalled
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Which of the following statements concerning the use of sildenafil for the treatment of erectile dysfunction is correct?
A. Sildenafil inhibits phosphodiesterase isoenzyme type V levels, thus increasing the concentration of cyclic AMP.
B. Sildenafil may cause a transient alteration in color vision.
C. Sildenafil may increase a patient's libido.
D. Sildenafil is hepatically cleared, and therefore no dose reduction is required for patients with impaired renal function.
E. Sildenafil is ineffective in the treatment of patients with diabetes mellitus who also have erectile dysfunction
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| -Eddie-
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Answer: B
Loss of blue/green discrimination probably b/c of inhibition of PDE-6 (a phosphodiesterase found in the retina).
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| Renegade
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The phosphodiesterase isoenzyme found in genitalia... isn't it V?
C. Sildenafil may increase a patient's libido. <- Placebo *cough*
___________________
«The desire to take medicine is perhaps the greatest feature which distinguishes man from animals.» W. Osler
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| -Eddie-
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Yes, PDE-5 in corpus cavernosum, vascular smooth muscle and platelets; PDE-6 in retina.
Sildenafil probably also inhibits PDE-6.
Page 478 Lippincotts Pharm (2nd edition).
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