fox
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1. A 74 yr old man has a cough. On auscultation of the right posterior chest, the patient’s spoken “ee” sounds more like “ay”. Which of the following conditions on the right is most likely:
A. Bronchopleural Fistula
B. Lower lobe consolidation
C. Midde lobe atelectasis
D. Pleural effusion
E. Pleural plaque
F. Pneumothorax
G. Sequestration
2. A homeless 38 yr-old man has a 3-month history of decreased appetite, generalized wasting, a low-grade fever, and worsening cough productive of blood, mucopurulent sputum. He has a 3-yr history of alcohol abuse. X-ray films of the chest show consolidation and cavitary lesions in the apices of the lungs. Which of the following is the most likely inflammatory and/or immune response in the lung?
A. Endothelial cell proliferation, vascular budding, fibroblasts
B. Epithelioid cells, multinucleated giant cells, caseation necrosis
C. Fibroblasts, Collagen deposition, replacement of intrinsic tissue
D. Macrophages, lymphocytes, hypergammaglobulinenia
E. Neutrophils, vascular congestion, exudate
3.A clone of cancer cells is resistant to vincristine, doxorubicin, and dactinomycin but not to methotrexate and various alkylating agents.
The mechanism of resistance is most likely to involve;
A. Absence of superoxide dismutase
B. Altered DNA Polymerase
C. Enhanced drug transport out of the cell
D. Inability to form polyglutamates
E. Increased DNase
1 & 2 are easy....let's crack the 3rd
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| me007
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#3
if enhanced drug transport out of cell = depression of drug uptake - the ans is C
http://www.ionchannels.org/showabstract.php?pmid=...
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| fox
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Thanks Me007
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| MRMAVERICK
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245/264/CS pass All on first attempt/2006 Grad/Need VISA
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| ssrpk
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which drug can be used to overcome this non-specific mode of drug resistance by tumor cells???
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| fox
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I searched but cud not find the answer...cud u tell us ssrpk?
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