Prep4USMLE Forum » USMLE Step 1 Forum » Microbiology Forum |   Q: Congenital infection

Author	14 Posts
fongch Forum Elite Topics: 71 Posts: 316	10/14/06 - 06:33 PM             #1 A newborn has multiple hemorrhagic cutaneous lesions and does not respond to sound. Head CT shows periventricular calcification. Which of the following infectious agents is the most likely cause of this child's presentation? A CMV B Herpes simplex virus C Rubella virus D Treponema pallidum E Toxoplasma Please explain when you answer. Thank you.
ManuNastai Transilvanian.. Topics: 55 Posts: 838	10/15/06 - 12:58 AM             #2 I must admit I cheated and I will cheat every time with this microbiology untill I'll learn it A see this also, not C because of this and not E because of this Edited by ManuNastai on 10/15/06 - 12:00 PM ___________________ "Love is the only inflamation of the heart that drains in the vagina" (translation after Dr Petre Florescu, Professor of Pathology, UMF "Iuliu Hatieganu", Cluj Napoca
klimt Forum Guru Topics: 27 Posts: 605	10/15/06 - 07:15 AM             #3 The child presents the classic triad of CMV infection: 1. blueberry muffin sd. - cutanate hemorrhages 2. deafness 3. CNS calcifications so it's A for sure ___________________ Traveler, there are no roads. Roads are made by walking.
fox Forum Guru Topics: 70 Posts: 727	10/15/06 - 11:36 AM             #4 I agree it could be A , but the butterfly muffin rash appears to be a part of rubella...& I picked this from Manu's links above: CONGENITAL RUBELLA SYNDROME (CRS). The most commonly described anomalies associated with congenital rubella syndrome are ophthalmologic (cataracts, pigmentary retinopathy, microphthalmos, and congenital glaucoma), cardiac (patent ductus arteriosus, peripheral pulmonary artery stenosis), auditory (sensorineural hearing impairment), and neurologic (behavioral disorders, meningoencephalitis, and mental retardation). Neonatal manifestations of congenital rubella syndrome include growth retardation, interstitial pneumonitis, radiolucent bone disease, hepatosplenomegaly, thrombocytopenia, and dermal erythropoiesis (so called "blueberry muffin" lesions). Mild forms of the disease can be associated with few or no obvious clinical manifestations at birth. The occurrence of congenital defects is up to 85% if infection associated with maternal rash occurs during the first 12 weeks of gestation, 54% during the first 13 to 16 weeks of gestation, and 25% during the end of the second trimester. ___________________ Aim High
fox Forum Guru Topics: 70 Posts: 727	10/15/06 - 11:38 AM             #5 Also manu ur 1st link is about amebiasis & not CMV!!!! ___________________ Aim High
ManuNastai Transilvanian.. Topics: 55 Posts: 838	10/15/06 - 12:04 PM             #6 hahaha! sorry! I don't know what happened there. I fixed it now; I might have tripped on technical stuff earlyer In the text there wasn't anything said about no muffins . it was klimt who said it. The thing that didn't fit in the 3 viruses was those skin lesions that I found in the CMV article stated: Congenital infection has a spectrum of manifestations but usually is silent clinically. Some congenitally infected infants who appear healthy at birth are later found to have hearing loss or learning disability. Approximately 10% of infants with congenital CMV infection have profound involvement evident at birth, with manifestations including intrauterine growth retardation, jaundice, purpura, hepatosplenomegaly, microcephaly, intracerebral calcifications, and retinitis. ___________________ "Love is the only inflamation of the heart that drains in the vagina" (translation after Dr Petre Florescu, Professor of Pathology, UMF "Iuliu Hatieganu", Cluj Napoca
fongch Forum Elite Topics: 71 Posts: 316	10/15/06 - 12:22 PM             #7 What about the CN VIII deafness? I seem to remember it is a presentation of congenital syphilis.
ManuNastai Transilvanian.. Topics: 55 Posts: 838	10/15/06 - 12:35 PM             #8 it is mentioned in all those 3, if I remember right ___________________ "Love is the only inflamation of the heart that drains in the vagina" (translation after Dr Petre Florescu, Professor of Pathology, UMF "Iuliu Hatieganu", Cluj Napoca
vallia Forum Guru Topics: 98 Posts: 889	10/16/06 - 05:12 PM             #9 what is it guys? A? ___________________ fight possessed
ManuNastai Transilvanian.. Topics: 55 Posts: 838	10/17/06 - 03:35 AM             #10 A ___________________ "Love is the only inflamation of the heart that drains in the vagina" (translation after Dr Petre Florescu, Professor of Pathology, UMF "Iuliu Hatieganu", Cluj Napoca
MRMAVERICK Forum Guru Topics: 41 Posts: 722	10/18/06 - 02:46 PM             #11 a
drpkaur Forum Guru Topics: 195 Posts: 808	10/28/06 - 08:11 PM             #12 a..
ed222 Forum Senior Topics: 4 Posts: 147	10/29/06 - 06:43 AM             #13 A calcifiied lesions in a newborn CMV Clue
jamdoc Forum Elite Topics: 30 Posts: 244	10/29/06 - 09:39 AM             #14 cerebral calcification and deafness can occur with both cmv and toxopalsmosis but im not sure if cutaneous leisons occur with cmv? A or E? ___________________ Dont worry.Nobody knows 100%

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