kashdoc21
Forum Senior
Topics: 52
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. Alcohol – hepatotoxin – decreased serum Albumin , Increased prothrombin time
can please someone explain the mechanism?
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| ssrpk
Forum Fanatic
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alcohol is a mitochondrial poison!
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| drfax
Forum Elite
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Alcohol is a mitochondrial poison which damage hepatocytes, therefore decreases albumin and anticoagulants (prothrombin) which is formed by the hepatocytes
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| vallia
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alcohol metabolism increase the NADH/NAD ratio in liver causing the intermediates of gluconeogenesis (pyruvate, OAA ) to be diverted into alternate pathways such as Fatty acids synthesis (hepatic steatosis). This is also the mechanism forh hypoglicemia in alcohol intoxication.
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