alpha 1 and alpha 2 receptors

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alpha 1 and alpha 2 receptors

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4 Posts

fictiondurden
Forum Junior

Topics: 19
Posts: 20

10/10/06 - 12:24 AM

What is the difference between alpha 1 and alpha 2 receptors? I think alpha 1 receptors increase blood pressure and alpha 2 receptors decrease blood pressure...is there anything else?

ManuNastai
Transilvanian..
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Topics: 55
Posts: 838

10/10/06 - 03:02 AM

alpha 2 are located on the presynaptic membrane and alpha1 postsynaptic. alpha1 is coupled w/ Gq protein and alpha 2 w/ Gi protein

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klimt
Forum Guru

Topics: 27
Posts: 605

10/10/06 - 03:46 AM

alpha1 - PK C - Gq protein - vasoconstriction
alpha2 - PK A - Gi protein - decrease sympathetic (which produces vc), decrease insulin

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ssrpk
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Topics: 154
Posts: 2,798

10/10/06 - 08:31 PM

be careful here, alpha2 receptors agonists acting peripherally can actually raise the blood pressure!

its the central effect of alpha-2 agonists that has antihypertensive effects!

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