mediocre
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<14>A 47-year-old woman presents with complaints of nervousness and
increased sensitivity to hot weather. She is diagnosed with
hyperthyroidism and prescribed propylthiouracil. What is
the principal mechanism by which this drug acts?
A. Decreasing the efficacy of TSH binding to the thyroid TSH receptor
B. Decreasing the rate of proteolysis of thyroglobulin
C. Increasing the amount of 3,3',5'-triiodothyronine (reverse T3; rT3)
D. Inhibiting deiodination of thyroxine (T4)
E. Inhibiting the uptake of iodide into the thyroid gland
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| asherif
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Correct answer is
D. Inhibiting deiodination of thyroxine (T4)
propylthiouracil acts by
1. inhibit oxidation (for Iodination)
2. inhibit coupling (combination of mono/di iodo thyronin to t3 & t4)
3. inhibit conversion of T4 (less active form) to T3 (more active form), which is D
feel free to correct me if I'm wrong 
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| vallia
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agree
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| klimt
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agree, D
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| MRMAVERICK
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d
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