fox
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Which of the following procedures or clinical signs is most specific for the diagnosis of infectious mononucleosis caused by the Epstein-Barr virus?
A. Laboratory diagnosis is based on the presence of "atypical
lymphocytes" and EBV-specific antibody
B. Growth in tissue culture cells
C. Heterophile antibodies in serum
D. Lymphadenopathy and splenomegaly on physical examination
E. B-cell lymphocyte proliferation
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| Leopard
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I think the answer must be "A".
Any other thought?
Best of luck
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| fox
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Hi leopard answer is not A. try again.
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| blueocean
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C - monospot test
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| smal
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A apprears most sp.none r that specific ......in my opinion.
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| bactitech
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Typical lab presentation is CBC, stat Monospot, and sometimes a strep screen to r/o Group A pharyngitis. Not all Mono presents with sore throat, but when it does, I remember someone at a workshop saying that it creates one of the ugliest sore throats you'll ever see.
I personally had Mono when I was twenty. I never had a sore throat. My symptoms were flu-like with night sweats. It's the only time in my life I ever had those, thank goodness. I was away at college and my bed became soaked with sweat every night. I felt absolutely terrible. I was on the third floor West wing, and laundry was in the basement of East wing. It was all I could do to get those sheets washed out. I ended up at the infirmary and they admitted me. They shipped off a mono test (we're talking 1968 technology here - WAY before I was involved in lab work) and it was positive. I have no idea what type of test they did on me. I had no liver or spleen involvement, thank goodness. I felt lousy for about a week. I stayed in the campus hospital for five days. They let me out to go to my chem labs though when I felt better (everyone knows you can't miss chem labs....).
The rapid Mono test we perform now only takes one drop of serum or EDTA plasma. It's pretty foolproof and I believe it is a CLIA waived test (supposedly any non-hospital person can do this).
Atypical or the old term "reactive" lymphs are an important clue also. You don't always necessarily see them, though.
I think C is the best answer of five ambiguous answers....
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| jsknetsdude
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most specific : EBV-specific antibody
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| fox
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Okay the answer given was B. I found this among the older posts here. No reference was quoted...neither was it mentioned where this q was from. The word 'most specific" was supposed to be the keyword.
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| fox
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http://www.prep4usmle.com/forum/comments.php?id=8...
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