gonzalfe
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A pt presents is diagnosed with AIDS with a CD4 cell count of 30/mm3. A western blot performed on his serum confirms the presence of antibodies to gp41 and gp120 but not against p24, p17 and p7p9. Why do antibodies to envelope antigens continue to be produced until the end, while antibodies to internal structural proteins disappear? Also explain why most patients will revert to being seronegative by the ELISA test? Hint: the Elisa test primarily tests for IgG antibodies against the p24 capsid protein.
Good luck...
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| zzhhhhhh1984
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1. envelope antigens is constantly exposed to serum ,hence induce the immue response to the end.while the internal structure is sequestered into CD4+ lymphocytes after infection,which can lead to immune tolerance.
2.as hinted ,p24 is a internal structure protein,which cannot be detected its antibody afterwards .that causes seroconversion to negtive
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