saadtazjam
Forum Elite
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Whats the Difference betwen Waldenstroms Macroglbulinemia and Multiple Myeloma?
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| MDcooper
Forum Guru
Topics: 211
Posts: 470
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Hmmm let me try
In WM,there is abnormal growth of plasma cells that make the blood very thick(hyperviscosity).It will affect immune system and person will have infections.the plasma cells produce excessive amounts of IgM.It is also called non hodgkin lymphoma.
In MM,there is abnormal growth of plasma cells that will cause bone pains andfractures bcz of production of Ig called M protiens.
more precisly,MM is clonal proliferation of single clone of plasma cells that produce mono clonal protiens called M protiens,while in WM there is abnormal production of single clone of lymphocytes that produce IgM.
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| saadtazjam
Forum Elite
Topics: 9
Posts: 160
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Can i add MGUS?I am trying to get clear concept?
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| Sea_gull
Forum Elite
Topics: 32
Posts: 179
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WM = abnormal proliferation of LYMPHOPLASMACYTOID CELLD (not of plasma cells) + Excessive IgM production + No bony lesions + Hepatosplenomegaly + Hyperviscosity syndrome ++++++
MM = Abnormal proliferation of PLASMA cells + Excess production of M proteine (which may be IgG ,IgA or IgM ) + bony lytic lesions + No hepatosplenomegaly + hyperviscosity syndrome +
Best of luck
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| saadtazjam
Forum Elite
Topics: 9
Posts: 160
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Can anyone explain Bleding disorders due to
1)VWD &hemophillia
2)Liver failure& Vit k Def
3)DIC
What happpens to BT/PT/PTT/Platelet count?any easy way to recognize these on exam question
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| chemamr
Forum Hero
Topics: 703
Posts: 4,463
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MMyeloma: Malignancy of plasma cells + replacement of the bone marrow (cytopenias) + bone destruction (osteoporosis, pathol fx, bone pain more common in the low back or ribs) + paraprotein formation (IgG more common than IgA. This is seen on serum protein electrophoresis -SPEP-, showing a monoclonal spike) + Renal failure (hypercalcemia, light chains) + recurrent infections by S.pneum and H.influ.
Waldenström's Macroglobulinemia: Malignancy of plasma cells + replacement of bone marrow + No lytic bone dz + monocloncal IgM paraprotein + Hyperviscosity more common than in MM + hepatosplenomegaly or lymphadenopathy (not in MM) + no renal failure.
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| saadtazjam
Forum Elite
Topics: 9
Posts: 160
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Thanks!Can you comment on the above?
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