klimt
Forum Guru
Topics: 27
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Which of the following segments of cystic fibrosis transmembrane conductance regulator CFTR is most likely located in a transmembrane segment?
A. Asp-Val-Leu-Thr-Glu-Lys-Glu-Ile
B. Glu-Glu-Thr-Glu-Glu-Glu-Val-Gln
C. Ile-Phe-Val-Leu-Ile-Trp-Cys-Leu
D. Lys-Ile-Lys-His-Ser-Arg-Gly-Arg
E. Ser-Thr-Gly-Ala-Gly-Lys-Thr-Ser
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| fongch
Forum Elite
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C?
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| blueocean
Forum Senior
Topics: 15
Posts: 195
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If is a transmembrane segment it is supposed to be nonpolar AA. Ile-Phe-Val-Leu-Ile-Trp-Cys-Leu has just one polar AA (cys) so I guess is C.
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| selsibeel
Forum Newbie
Topics: 1
Posts: 10
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Totally C. Remember that in CF patients, the PHE is part of the normal protien, but due to the defect in chromosome 7 that 3 nucleutide base code is deleted in some F508 part of the gene.
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| MD_toronto
Forum Junior
Topics: 2
Posts: 27
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C.
Also, to remember that N terminal signal sequence on mRNA is hyrophobic amino acid sequece that direct protien synthesis in rER.
This way you can eliminate choice w/ hydrophilic amino acids(ABE).
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| klimt
Forum Guru
Topics: 27
Posts: 605
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You are correct, ans is C
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