fomepizole

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fomepizole

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6 Posts

docarchana
Forum Guru

Topics: 70
Posts: 515

09/29/06 - 05:13 PM

what is the mechanism of action?

drugAddict
Forum Newbie

Topics: 3
Posts: 12

09/29/06 - 05:23 PM

Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.

Ethylene glycol is first metabolized to glycoaldehyde which then undergoes further oxidation to glycolate, glyoxylate, and oxalate. It is glycolate and oxalate that are primarily responsible for the metabolic acidosis and renal damage that are seen in ethylene glycol poisoning.

Methanol is first metabolized to formaldehyde and then undergoes subsequent oxidation via formaldehyde dehydrogenase to become formic acid. It is formic acid that is primarily responsible for the metabolic acidosis and visual disturbances that are associated with methanol poisoning.

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docarchana
Forum Guru

Topics: 70
Posts: 515

09/29/06 - 05:36 PM

thanku pharmacist, business magnet, doctor..

drugAddict
Forum Newbie

Topics: 3
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09/29/06 - 05:46 PM

and consequently an old man.....

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Leopard
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09/29/06 - 05:53 PM

drugAddict wrote:
and consequently an old man.....

Thread extension

Which vitamins can as an adjunct in the therapy of Methanol and Ethylene Glycol poisoning ??

Best of luck

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drugAddict
Forum Newbie

Topics: 3
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09/29/06 - 06:11 PM

IV THIAMINE & PYRIDOXINE

1) Thiamine (B1) to stimulate the conversion of glyoxylate to alpha-hydroxy-beta-ketoadipate, a non-toxic metabolite.

2) Pyridoxine (B6) to allow adequate stores of cofactor necessary for the conversion of glyoxylate to nontoxic glycine

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