study_ing
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i donbt remember immuno very well but ill guess a.
i think it correseponds to type 2 hypersensitivity.
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| study_ing
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actually this i sa confusing q. in sle both type 2 and 3 were involved.
insulin resistence cud be attributed to auto ab but this uwas nto 100 % shown i think.
c probably involves type 4 rxn
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| ssrpk
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its definitely insulin resistance![if considering treatment response] as giving insulin to such patients lowers the glucose level [increase substrate conc.] ; same is the mechanism of improvement in pts with myasthenia gravis with edrophonium!
from an immunologican point of view it cud be A or E
but i guess i'll go with d!
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| sunny2
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It is Insulin resistence -sure 
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| Shaina
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i know most common cause is hyperparathyroidism. can anything else be added to this topic.
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| MDcooper
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yes its insulin resistance as U all said.it is antibodies against insulin receptors as compared to antibodies against ach receptors...(I am not so convinced with this)..
SLE is due to circulating immune complexes.DM type 1 and idiopathic addisons is due to humoral responses.and bullous pemphigoid is due to antibodies against basement membrane.
hey guys!is type 1 DM due to antibodies or type 2.can someone recall and revise this?`
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| Shaina
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sorry i wanted to post abt "ASx hypercalemia etilogy" in forum ,anyways can u add on anyone,pls
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| ssrpk
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i never knew tht type II DM has some relation with antibodies against the receptor but anyway insulitis is a predominant feature of type I, and type II is basically insulin resistance for a variety of reasons!
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| robin082006
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d
mentioned in Kaplan's
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| tolito
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i also think it is D. cos type 2 dm is associated with ab against insulin receptors (type 2 hypersens).just as myasthenia gravis is ab against ach receptors, same as graves.
pemphigus vulgaris is the other one that is type 2 non cytotoxic. i dont know about pemphigoid.
type 1 dm is t cell mediated in type 4 reaction. there are antibodies against islet cells.
sle also gives type 2 reaction but it will be of the cytotoxic kind cos that is the one associated with production of immune complexes. the main sle reactions are type 3.
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| study_ing
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bullous pemphigoid is type 2 as well.
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