hyperpigmentation

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Prep4USMLE Forum » USMLE Step 2 CK Forum » Internal Medicine Forum

hyperpigmentation

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MDcooper
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09/29/06 - 09:43 AM

what is the mechanism of hyper pigmentation in addison's disease????

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star1
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09/29/06 - 10:20 AM

Addison's disease => NO cortisol => lead to ACTH level to rise due to positive feedback...

ACTH has in its structure some resemblance with Melanocyte stimulating hormone and this MSH produces Hyperpigmentation

MDcooper
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09/29/06 - 10:25 AM

thanx a lot

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tolito
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09/30/06 - 06:49 PM

same mech for acth secreting cells of squamous cell carcinoma of lung.

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chemamr
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10/01/06 - 02:01 PM

good explanation star1 nod

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tolito
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10/01/06 - 10:21 PM

correction, acth secretion is by small cell ca of lung and not squamous cell ca. sorry about the wrong info sad

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chemamr
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10/02/06 - 07:26 AM

oh yes. PTHrp is by squamous cell CA. ACTH, SIADH for example by small cell CA.

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