X-Ray
Forum Senior
Topics: 25
Posts: 139
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Which of the following decreases the circulating levels of norepinephrine?
a.-amphetamine
b.-clonidine
c.-phentolamine
d.-phenoxybenzamine
e.-prazosin
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| Leopard
Forum Guru
Topics: 30
Posts: 401
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clonidine
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| X-Ray
Forum Senior
Topics: 25
Posts: 139
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excellent deduction
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| fox
Forum Guru
Topics: 70
Posts: 727
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Conidine is the only centrally acting drug. The rest are ganglion blockers (peripherally acting)
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| X-Ray
Forum Senior
Topics: 25
Posts: 139
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correct is is a alpha-adrenoreceptor agonist and decreases sympathetic outflow and therefore decreasing norepinephrine
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| Leopard
Forum Guru
Topics: 30
Posts: 401
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MOA of cloinidine , being alpha -2 receptor agonist, blocks sympathetic outflow from Medulla oblongata.
Epinephrine and Nor epinephrin from Adrenal medulla is secreted under this stimulus of this outflow.
So ,Clonidine is the choice.This effect of Cloinidine is the basis of Clonidine suppression test for Pheochromocytoma.
Best of luck
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