docswapna
Forum Senior
Topics: 61
Posts: 229
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I'm very confused with the single gene disorder question on NBME 2. It shows a pedigree with different cancers in the family down generations -- the cancers being Breast (age of onset (AOG) 28, 36 & 51), myxofibrosarcoma (AOG 48), medulloblastoma ( AOG 5) and rhabdomyosarcoma (AOG 8). The choices were:
anticipation, genetic heterogeneity, incomplete penetrance, multifactorial inheriatance and variable expressivity.
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| blueocean
Forum Senior
Topics: 15
Posts: 195
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The question told you is about the single gene defect?
Because if is single gene defect I guess is about variable expressivity.
If they didn't talk about single gene defect is about multifactorial inheritance ( multiple loci involved).
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| ManuNastai
Transilvanian..
Topics: 55
Posts: 838
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agree w/ blueocean, should be expresivity
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"Love is the only inflamation of the heart that drains in the vagina" (translation after Dr Petre Florescu, Professor of Pathology, UMF "Iuliu Hatieganu", Cluj Napoca
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