hyperbilirubinemia

Prep for USMLE Forum

» Log in | Register

Forum

Step 1

Match

Prep4USMLE Forum » USMLE Step 1 Forum » Pathology Forum

hyperbilirubinemia

Author

12 Posts

docswapna
Forum Senior

Topics: 61
Posts: 229

09/26/06 - 07:33 PM

A 42 year old man has temperature of 39.2C {102.6F} and mild jaundice 2 days after transfusion of packed red cells for the treatment of chronic anemia .Laboratory studies show hyperbilirubinemia and a mild increase in serum LDH activity. Whcih of the following findings will most likely be observed on analysis of peripheral blood cells ?

a.-complement protein C3bi bound to monocytes
b.-degranulated neutrophils
c.-erythrocyte ghost
d.-HLA-DR upregulation in circulating CD3+ T lymphocytes
e.-immunoglobulin bound to erythrocytes
f.-nucleated erythrocytes

young_doc
Forum Guru
avatar

Topics: 56
Posts: 735

09/26/06 - 08:35 PM

e?

___________________
First Aid is my Bible...

smal
Forum Guru
avatar

Topics: 140
Posts: 727

09/26/06 - 09:09 PM

d.

hla upregulation coz of blood transfusion and Tcell activation leading to fever and increased RBC destruction leading to hyperbill.

___________________
remedy for weakness is not brooding over it ,but thinking of strength.

docsrinu
Forum Elite

Topics: 26
Posts: 213

09/26/06 - 09:20 PM

i guess E is the ans..

fox
Forum Guru
avatar

Topics: 70
Posts: 727

09/26/06 - 11:53 PM

D & E. Both appear to be a close call. However D seems to fit better. Lets wait for the leapords & tigers to voice their opinion.

___________________
Aim High

docsrinu
Forum Elite

Topics: 26
Posts: 213

09/26/06 - 11:56 PM

yup im also waiting for reply from leopard. he is not active for the last couple of days.

alexaE
Forum Elite
avatar

Topics: 23
Posts: 334

09/27/06 - 12:52 AM

im saying e

___________________
veni vidi...vincam

sridevibandaru24
Forum Guru

Topics: 33
Posts: 434

09/28/06 - 05:32 PM

the question stem says analysis of periperal blood cells. If we think it asperipheral blood smear then the answer will be either F(thinking that in chronic anemia reticulocyte count is elevated) Or C(thinking that haemolysis will result in enucleated RBCs that is erythrocyte ghosts)

docarchana
Forum Guru

Topics: 70
Posts: 515

09/28/06 - 06:05 PM

sridevibandaru24 wrote:
the question stem says analysis of periperal blood cells. If we think it asperipheral blood smear then the answer will be either F(thinking that in chronic anemia reticulocyte count is elevated) Or C(thinking that haemolysis will result in enucleated RBCs that is erythrocyte ghosts)

what is meant by erythrocyte ghost?

Tiff
Forum Guru

Topics: 54
Posts: 561

01/29/08 - 01:22 PM

#10

Anyone know the correct answer to this old posted question? What is an erythrocyte ghost?

pr20
Forum Senior
avatar

Topics: 24
Posts: 180

01/29/08 - 05:04 PM

#11

My choice is E.
Is it hemolytic transfusion reaction due to antibodies against donor RBC antigens---->type 2 hypersensitivity reaction----->antibodies bound to erythrocytes?

Ig F
Forum Elite
avatar

Topics: 3
Posts: 436

01/31/08 - 01:25 PM

#12

yes its E as it is hemolytic transfusion reaction.......antidodies of the host/recepient bind to the donor rbc antigens and destroy them resulting in hyperbilurubinemia....type II hypersensitivity reaction....... nod

___________________
i m not perfect but i wanna get close to it......

You don't have permission to post.