docswapna
Forum Senior
Topics: 61
Posts: 229
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Family with father ,grandfather and grandmother suffering from gardner's syndrome.father has 4 children.what are the chances that atleast one child has inherited the gardner's syndrome allele?
A.1/4
B.1/2
C.3/4
D.13/16
E.15/16
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| fox
Forum Guru
Topics: 70
Posts: 727
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U had posted a similar q (wardenburg's). We lesser mortals got stumped. Could u tell us watz the answer for both the Q?
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| docswapna
Forum Senior
Topics: 61
Posts: 229
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for wardenbugs ur right. 1/8
1/2x1/2x1/2
try this. i will post the ans later..
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| alexaE
Forum Elite
Topics: 23
Posts: 334
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here it is E
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veni vidi...vincam
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| ManuNastai
Transilvanian..
Topics: 55
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E
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| Palaniappan
Forum Senior
Topics: 30
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Can anyone exlain the answer E?
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| nrkmani
Forum Newbie
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gardener is autosomal dominant.
1 st genereration risk is 50%
2 nd gen risk is 25% (1/4)
total probability of all 4 children affected is 1/4 *1/4*1/4*1/4 =1/16
probability of atleast one child affected=1-1/16=15/16
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| drbin
Forum Guru
Topics: 27
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hw could the risk in first gen be 50 % bs both grandfather and gr mother affected, so chance must be 75%
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| drbin
Forum Guru
Topics: 27
Posts: 535
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Ans E?
1st gen
Aa * Aa
AA Aa Aa aa
So chance that father has diseased allele is 3/4
2nd gen
Aa * aa
Aa Aa aa aa
so risk is 50 % ie 1/2
chance for all 4 to be affected is 1/2 * 1/2 * 1/2 * 1/2 = 1/16
Risk of atleast 1 having disease allele = 1-1/16= 15/16
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