docarchana
Forum Guru
Topics: 70
Posts: 515
|
An elderly (80 yrs) is scheduled for endoscopy for evaluation of rectal bleeding. A standard dose of midazolam is administered intravenously when the patient is admitted to the endoscopy suite. A few minutes later, he develops cyanosis and labored respirations and required ventilation with an oxygenated resuscitation bag. An age-related increased in which of the following is the most likely cause of these adverse effects?
1. Volume of distribution
2. Plasma protein binding
3. Sensitivity to sedatives
4. Metabolite formation
5. Enerohepatic recycling
|
| young_doc
Forum Guru
Topics: 56
Posts: 735
|
3?
___________________
First Aid is my Bible...
|
| fox
Forum Guru
Topics: 70
Posts: 727
|
My guess is 2.
___________________
Aim High
|
| lightray
Forum Newbie
Topics: 1
Posts: 18
|
I think it is 4) metabolite formation ...as Geriatric patients lose Phase 1 metabolism.I am not sure!!!
|
| drpkaur
Forum Guru
Topics: 196
Posts: 810
|
4???
|
| drugAddict
Forum Newbie
Topics: 3
Posts: 12
|
A tricky question, the elimination half-life of midazolam is increased in people above 80.
This change is because of a lower total body clearance and increase in Vd of midazolam.
The ANSWER IS "A"
Edited by drugAddict on 09/29/06 - 05:21 PM
___________________
There are three types of people in this world: those who make things happen, those who watch things happen and those who wonder what happened.
|
| smal
Forum Guru
Topics: 140
Posts: 727
|
Résumé / Abstract
Advancing age is characterized by impairment in the function of the many regulatory processes that provide functional integration between cells and organs. Therefore, there may be a failure to maintain homeostasis under conditions of physiological stress. The reduced homeostatic ability affects different regulatory systems in different subjects, thus explaining at least partly the increased interindividual variability occurring as people get older. Important pharmacokinetic and pharmacodynamic changes occur with advancing age. Pharmacokinetic changes include a reduction in renal and hepatic clearance and an increase in volume of distribution of lipid soluble drugs (hence prolongation of elimination half-life) whereas pharmacodynamic changes involve altered (usually increased) sensitivity to several classes of drugs such as anticoagulants, cardiovascular and psychotropic drugs. This review focuses on the main age-related physiological changes affecting different organ systems and their implications for pharmacokinetics and pharmacodynamics of drugs.
Revue / Journal Title
YA I THINK A.
___________________
remedy for weakness is not brooding over it ,but thinking of strength.
|
| vallia
Forum Guru
Topics: 98
Posts: 889
|
i think it's 4
___________________
fight possessed
|
|
| |
| | | | | | | | |
