Musuq
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A series of experiments is performed to determine the mechanism by which a pharmacologic agent traverses cell membranes and accumulates within target cells. The rate of transport depends on the concentration of the drug only. When the extracellular concentration of the agent exceeds 10 mM, no further increase in the rate of uptake is observed. Structurally similar compounds pass through the cell membrane, but at a lower rate. Ouabain, an inhibitor of Na+/ K+ ATPase, fails to inhibit transport. Which of the following is the most likely mechanism by which this agent enters cells?
A) Antiport
B) Facilitated diffusion
C) Ion-gated coupling
D) Simple diffusion
E) Symport
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| jole
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B-carrier mediated thus can be saturated and does not need Na pump thus not inhibited by oubain
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| klimt
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agree
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| ManuNastai
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why isn't it D? I think all that mumbo-jumbo with Na are distractors
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| Addicudo
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Yes .. It is B .. PLus the fact that if it were by Simple Diffusion then .. even after 10Mm ... to balance out the Intra and Extracellular compartments .. Diffusion would still have taken place .. !!
What I didnt get in this question is this 'Structurally similar compounds pass through the cell membrane, but at a lower rate' .. What does this refer to ?
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| smal
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it says,the flow of drug depends totally on the drug conc,in facilitated diff. its limited by the transporter conc....
so i think D
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| fox
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structurally similar could refer to symport .....whaddya say?
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| vallia
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D,
i don't think they are refering to symport which is transport in the same direction of 2 different substances and use enrgy from Na/K pump
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