mahendra
Forum Guru
Topics: 173
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A 55-year-old woman notes a gradually increasing
number of episodes of cramping abdominal pain and
diarrhea that occur after ingestion of milk products.
A decrease in which of the following best explains her
condition?
(A) Ability of enterocytes to transport calcium
(B) Ability of Paneth cells to secrete lactase
(C) Ability of Paneth cells to secrete lysozyme
(D)Galactosidase activity at the cell
surface of enterocytes
(E) Sucrase activity within lysosomes of
enterocytes
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| asmi
Forum Hero
Topics: 1043
Posts: 4,609
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I GUESS B
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| step1taker
Forum Senior
Topics: 2
Posts: 105
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D.
Im not sure if Paneth cells secrete lactase, from what i recall they don't.Paneth cells are large secretory cells with coarse granules found at the blind ends of the crypts of lieberkuhn.
Kindly enlgihten me if they secrete lactase.thanks 
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| Idiopathic
Forum Guru
Topics: 19
Posts: 641
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Paneth cells do not secrete lactase. All disaccharidases are brush border enzymes, located in the microvilli of the duodenum (?). This is a classic presentation of lactose intolerance (except for flatulence), so it is a brush border enzyme deficiency, and D is the answer.
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| asmi
Forum Hero
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Iam sorry i was wrong paneth cells don't secrete lipases.
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| meg
Forum Guru
Topics: 62
Posts: 806
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though none of the others other than D seem right, I thought brush border enzymes were disaccharidases.. galactosidase is monosacharidase.. I know fructokinase(monosacharidase) is present in the brush border, so probably galactosidase also is possible (though lactase would have been the easiest to identify the lactose intolerance).
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