musali
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i had a question in diagnosing lactose intolerance in a patient.
both clinitest and hydrogen breath test were available as an answer choice,
the corrent choice was hydrogen breath test, why is this choice better than clinitest given both the choices are associated with lactose intolerance?
thanks
mustafa
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| tolito
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i dont think lactose is a reducing agent so clinitest will be negative.
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| tolito
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teh reducing sugars are glucose, fructose and sucrose
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| saadtazjam
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As far as i know there are 3 tests to detect lactose intolerance
1)LTT:Lactose tolerance test:lactose fluid-2hr period-persons blood sugar decreases(unlike increase in normal)
2)Hydrogen breath test:lactose beverage:raised levels of hydrogen in breath
3)stool acidity test:-infants and children-stool lactic acid and glucose measurement
hope that helps
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| study_ing
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musali , did they give u a description of the test or simply name it.. i remember i got a q wrong similarly, in which they had sneaked in the term "oxidizing " substances rather than reducing one.
( i feel kaplan used to explain y the remaining choices are not the amswer so much better...UW got great Qs, but their explanations are not to the mark)
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| musali
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study_ing, tolito, you guys are correct, but im still confused, i went back and looked at it. the answer choice says "choice A. positive clinitest for oxidizing substance."
so here is the answer courtesy of the education objective from UW regarding that question.
"Lactose Intolerance is characterized by a postive hydrogen breath test, a positive Clinitest of stool for REDUCING substances, and an increased stool osmotic gap."
ok so let me get this straight, i picked positive clinitest for OXIDIZING substance and that was wrong. and you guys are syaing lactose is NOT a reducing substance like glucose, fructose and sucrose. but why then would the educational objective say a poistive clinitest of stool for reducing substance?
saadtazjam - UW also said that the hydrogen breath test has largely replaced the LTT due to the time and finacial cost.
someone help?
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| study_ing
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u made exactly my mistake..the clinitest is fo rreducing substances. hence the option which says clinitest for oxidising substances is wrong
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| musali
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ok i understand that the option of clinitest for oxidizing substane is wrong because it is for reducing agent. i get that, but then why in the educational objective it says positive clinitest for reducing substance when tolito mentioned that lactose is NOT a reducing sugar?
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| Sea_gull
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musali wrote:
ok i understand that the option of clinitest for oxidizing substane is wrong because it is for reducing agent. i get that, but then why in the educational objective it says positive clinitest for reducing substance when tolito mentioned that lactose is NOT a reducing sugar?
A reducing sugar is a type of sugar with an aldehyde group. This allows the sugar to act as a reducing agent, for example in the Maillard reaction and Benedict's reaction. Reducing sugars include fructose, glucose, glyceraldehyde, lactose, arabinose and maltose. All monosaccharides which contain ketone groups are known as ketoses, and those which contain aldehyde groups are known as aldoses. Significantly, sucrose is not a reducing sugar.
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| tolito
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i got my information wrong. lactose indeed is a reducing sugar.
maybe cos the clinitest is not specific for lactose alone. possibly any cause of malabsorpsion will give a positive clinitest.
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| musali
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sea_gull, thank you, its all cleared up,
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