blueocean
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HbNl: AAGUAUCACUAAGCUCGC
HbCr: AAGAGUAUCACUAAGCUCGCUUUC ... UAU UAA
Hemoglobin is isolated from the erythrocytes of a young child with anemia. Hemoglobin electrophoresis reveals the presence of an unstable hemoglobin, known as hemoglobin Cranston (HbCr), containing an abnormal β-globin chain. The normal sequence of the β-globin gene (HbNl) and the sequence of the HbCr β-chain are presented above. Which of the following would account for the development of HbCr?
A. A frameshift mutation resulted in the deletion of several amino acid residues in the β-chain
B. A mutation in the stop codon resulted in elongation of the β-chain
C. A point mutation resulted in the insertion of a stop codon in the β-chain
D. A two base pair addition resulted in the elimination of a stop codon in the β-chain
E. A two base pair deletion resulted in truncation of the β-chain
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| vanshita
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| sridevibandaru24
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| drbin
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A
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| ashfaque
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D
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| lq2006
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D. A two base pair addition resulted in the elimination of a stop codon in the β-chain
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