mediocre
Forum Elite
Topics: 37
Posts: 229
|
a 60yr old woman had problems related to movements for 5 yrs,on phys exm.---cog wheel rigidity,festinating gait.Tt with levodopa cond. improved, 2 yrs later marked cognitive decline ....died of aspiration pneumonia. on autopsy mild cerebral atrophy, loss of subst.nigra pigment. Miroscopically loss of pigmented neuron ,the rmaining neurons show spheroidal,intraneuronal,cytoplasmic,eosinophylic inclusions.Immunohistochemical staining of which of following protiens is most likely to b positive
1-alpha-Synuclein
2-Amyloid precursor prtoein
3-Apolipoprotein-e
4-Huntingtin
5- Presenilin
6-Tau protein
___________________
"Do not worry if you have built your castles in the air. They are where they should be. Now put the foundations under them." - Henry David Thoreau
|
| goodyear
Forum Guru
Topics: 16
Posts: 409
|
tau protein
|
| mediocre
Forum Elite
Topics: 37
Posts: 229
|
please explain....by the way dis is not the ans.
___________________
"Do not worry if you have built your castles in the air. They are where they should be. Now put the foundations under them." - Henry David Thoreau
|
| fox
Forum Guru
Topics: 70
Posts: 727
|
you will find Lewy bodies on microscopy & these are the inclusion bodies. They are positive for alpha- synuclein. So Answer is 1.
The primary constituent of LBs is alpha-synuclein, a presynaptic protein, the function of which is unknown. Neurofilament proteins and ubiquitin are other important constituents of LBs.
___________________
Aim High
|
| mediocre
Forum Elite
Topics: 37
Posts: 229
|
___________________
"Do not worry if you have built your castles in the air. They are where they should be. Now put the foundations under them." - Henry David Thoreau
|
| goodyear
Forum Guru
Topics: 16
Posts: 409
|
Whatz the Dx. ?
this is not a case of Parkinson's?
|
| mediocre
Forum Elite
Topics: 37
Posts: 229
|
symptoms of parkinsons(rigidity,tremors) + symptoms of Dementia=
LBD (Lewy Body Dementia)
___________________
"Do not worry if you have built your castles in the air. They are where they should be. Now put the foundations under them." - Henry David Thoreau
|
| twesting2173
Forum Senior
Topics: 7
Posts: 65
|
aka diffuse lewy body disease. you'll find inclusions in the cortex....Park spares the cortex. later gators.
|
|
| |
| | | | | | | | |
