khorshid
Forum Guru
Topics: 32
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what is MOA of mirtazapine? in pharm it says it blocks presynaptic alpha2 receptor, but in behav it says it blocks 5-HT2 and 5-HT3.
So which one?
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| new_n_lost
Forum Hero
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its both according to Katzung review 7th ed pg 256
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| drpkaur
Forum Guru
Topics: 196
Posts: 810
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It is thought to work by blocking presynaptic alpha-2 adrenergic receptors that normally inhibit the release of the neurotransmitters norepinephrine (noradrenaline) and serotonin, thereby increasing active levels in the synapse. Mirtazapine also blocks post-synaptic 5-HT2 and 5-HT3 receptors—an action which is thought to enhance serotonergic neurotransmission while causing a low incidence of side effects.
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| khorshid
Forum Guru
Topics: 32
Posts: 591
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new_n_lost and drpkaur thank you both:-)
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| drfax
Forum Elite
Topics: 21
Posts: 232
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It is doing BOTH
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