docsrinu
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A 28-year-old man has prolonged episodes of wheezing, dyspnea, and anxiety that are relieved by β-adrenergic agonists. The major mediator of his condition is
A) bradykinin
B) eosinophil chemotactic factors
C) leukotrienes
D) prostaglandin E
E) TXA2
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| vanshita
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C
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| hope99
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A ?
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| docarchana
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both leukotrienes & TXA2 cause brochoconstriction. so ans shud be C or E.
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| Allison
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Answer: C Leukotrienes causes anaphylaxis and brochoconstriction (role in asthma)
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| ManuNastai
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C
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| ssrpk
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both leukotrienes and TXA2 coz brochoconstriction, but tht does'nt mean tht both are implicated as being the major mediator in asthma!
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| mediocre
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I thoght Txa2 caused only Vasoconstriction,,does it cause Broncho constriction aswell??? plz give some ref,thanx
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| dreamer
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i guess so.it is in fa page 417 
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| inkspot
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it is C
i was just wondering how is anxiety relieved from b2 agonist? b2 agonist causes palpitations and anxiety!
b1 antagonists are anxiolytic in hyper thryooid pts
may be when his asthama is relieve the patient is anxiolytic? 
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| Mikeland
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"A" Bradykinin is a potent endothelium-dependent vasodilator, causes contraction of non-vascular smooth muscle, increases vascular permeability and also is involved in the mechanism of pain. In some aspects, it has similar actions to that of histamine, and like histamine is released from venules rather than arterioles.
If the Pt respond to B agonist, thgere is not inflamatory related responce, all others answers are related to inflamatory respon..
That why we used B adre... and esteroid in pt with asthma asthma
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| Mikeland
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I forgot, B agonist do not relive anxiety directly, just figure out a pt with dyspnea and you relive it....the anxiety gone!
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| Addicudo
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C) Leukotrines .. Major mediators of Bronchoconstriction ..
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| Mikeland
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leukotriene cause broncoconstric... u are right, however, mechanism of accion is throught Histamin....TX too. That's why I go for A..
I am not comppletly sure.
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| inkspot
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bradykinin causes angioedema! not asthama! bradykinin is increased by ACE inhibitors * captopril * not aspirin
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| lq2006
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C
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