smal
Forum Guru
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which of the foll. immunosupressive agents acts in the lymphocyte by complexing to and inactivating lymphocyte specific calcineurin
1.antilymphocyte globulin
2.azahioprine
3.corticosteroides
4.cyclosporine
5.OKT3 monoclonal antibody
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| docsrinu
Forum Elite
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i think OKT3
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| suv
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cyclosporine
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| docarchana
Forum Guru
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suv is right. its also the mechanism of action of tacrolimus (FK506).
can some one explain the mechanism of OKT3?
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| smal
Forum Guru
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about OKT3 monoclonal antibodyAnti-CD3 monoclonal antibody that exerts immunosuppressive effects by inducing peripheral T-cell depletion and modulation of the T-cell receptor complex (CD3/Ti). This biochemically purified IMMUNOGLOBULIN G is obtained through the fusion of mouse myeloma cells to lymphocytes from immunized animals to produce hybridomas that secrete specific antibodies to the T3 (CD3) antigens of human T-lymphocytes. It is often used as an immunosuppressive agent in transplantation.
calineurin is required for uptake of enzymes by lysosomes from golgibodies.....
but i dont 've a clue to the ans.
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remedy for weakness is not brooding over it ,but thinking of strength.
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| docswapna
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thanku small
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| Allison
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4. cyclosporine: binds to cyclophilin, decreases calcineurin (cytoplasmic phosphatase), decreases activation of T-cell transcription factor, decrease Il-2, Il-3 and interferon- gamma.
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| Musuq
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You Rock Allison!!! 
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| Musuq
Forum Guru
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Ref. Kaplan pg. 315 Pharm Notes
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| sattar
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The answer is C.cyclosporine 
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