musali
Forum Senior
Topics: 17
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I had a practice questions that had dealt with wilsons's disease and while readingup a quick review of it, i read that it can also stain positive for PAS.(periodic acid-schiff). however i know that alpha 1 antitrypsin deficiency disease also is pos for PAS.
when i had anohte quesion that dealt with it i had a choice btwn the two, this time i picked wilsons, but i got this wrong as well. so which is it..positive pas for wilsons or A1AT disease?
thank,
mustafa
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| musali
Forum Senior
Topics: 17
Posts: 76
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what i think i figured it out, im confusing wilson's disease with whipple disease with the PAS staining, bc whipple disease has positive PAS staining in the lamina propria.
thanks for looking!
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| study_ing
Forum Fanatic
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 ..and how do we dx wilson's?
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| saadtazjam
Forum Elite
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serum cerulloplasmin????
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| study_ing
Forum Fanatic
Topics: 180
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hi serum and urinary copper, low serum ceruloplasmin
HEPATIC copper content>250 ug/g dry wt
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| study_ing
Forum Fanatic
Topics: 180
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The presence of Kayser-Fleischer rings and ceruloplasmin levels of less than 20 mg/dL in a patient with neurologic signs or symptoms suggest the diagnosis of Wilson disease
If a patient is asymptomatic, exhibits isolated liver disease, and lacks corneal rings, the coexistence of a hepatic copper concentration of more than 250 mg/g of dry weight and a low serum ceruloplasmin level is sufficient to establish a diagnosis.
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