drpkaur
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Didanosine is a nucleoside analog sometimes used to treat HIV infections.this drug is converted metabolically to 2',3'-dideoxyATP,which blocks DNA chain elongation when it is incorporated into viral DNA synthesized by reverse transcriptase ..why does DNA synthesis stop???
1.the analog becomes covalently bound to reverse transcriptase,thus inactivating the enzyme.
2.proofreading is inhibited.
3.there is no 3'-hydroxyl group to form the next phosphodiester bond.
4.the analog cannot hydrogen bond to the RNA template.
5.incorporation of the analog initiates rapid degradation of the newly synthesized strand..
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| star1
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3.there is no 3'-hydroxyl group to form the next phosphodiester bond.
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| blueocean
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C
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| blueocean
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sorry- 3
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| drpkaur
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could you give your explanation plz...
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| blueocean
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Didanosine is a nucleoside reverse transcriptase inhibitor .
ddI has to mechanisms:
-competitively inhibits binding natural nucleosides to the binding site of reverse transcriptase
-acts like chain terminator via insertion into growing DNA chain. Because lacks a 3'HO group on the ribose ring attachment of the next nucleotide is imposible.
(PHARMA -KAtzung&Trevor)
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| suv
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Blue ocean thanks for the explanation
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| drpkaur
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thanx for nice explanation ...........
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| blueocean
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