aisha2
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ochronosis ,, i remember doin this but i just cant remember what it was
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| new_n_lost
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Ochronosis is the bluish black discoloration of certain tissues, such as the ear cartilage and the ocular tissue, seen with alkaptonuria, a metabolic disorder. Additionally, ochronosis can occasionally occur from exposure to noxious substances, such as phenol, trinitrophenol, resorcinol, mercury, picric acid, benzene, hydroquinone, and antimalarials.
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| Cedrick
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sweet thanks
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| Leopard
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Basic defect is in Tyrosine metabolism pathyway
Enzyme affected = Homogentisate oxidase
And this disease is also known as Alkaptoneuria
Best of luck
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| aisha2
Forum Guru
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thankx Leopard ,
Homogentisate oxidase def ---------------> homogentisic acid accumulates causin the ts discoloration and also turns the urine black when oxidized and osteoarthritis (intervertebral disk)
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