aisha2
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i know this sounds like very basic thing but i could not understand why the LVEDV (left ventricular end diastolic volume) is decreased in septoc shock.
goljan rapid review says its bcoz of neutrophil emigration from pul.capillaries in to alveoli
i just dont get this point can any one plz explain this to me.
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| Cedrick
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there is nothing simple about this subject
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| aisha2
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so what do u think
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| Cedrick
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Well in septic shock there is a multiple organ failure,hypotension {refractive}
there is a massive vasodilatation beause the body is fighting back but it can't there is a systemc infection
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| aisha2
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septic shock = vasodilatin, due to endotoxin induced releas of NO, PGI2 & (alterntive complement) C3a & C5a(anaphylotoxins)..............
this means,vasodilation--------------> inrease TPR/PVR(resistance)-------------------->increased CO
and the book says decreased LVEDV ?????? dont get this , i mean with an increase in CO how can u have a decrease in LVEDV
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| Cedrick
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Yes Vasodilatation
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| Leopard
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Septic shock has two phases
Hypedynamic phase --- in which CO is high and CVP is low
Hypodynamic phase ---- in Which CO is low and CVP is high
Initial there is decrease in venous return in the presence of excessive CO (due to increased contractility) and peripheral vasodilation .Venodilation causes decrease in venous return which in turn causes decrease in LVEDV. But this is in Hypedynamic state
In the later phase LVEDV should increase
Best of luck
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| Cedrick
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good that you found it
likewise good luck
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| aisha2
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thankx alot Leopard , it all makes sence now
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| Leopard
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Welcome dear
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| Cedrick
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love you to dear
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