Cedrick
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An Obese 62 year old woman is brought to the emergency department in a coma by emergency medical technicians {EMT}
The EMT report that she said she had palpitations and double vision before becoming unresposive 10 minutes ago
A medic alert bracelet shows that she has hypertension and type 2 diabetes mellitus
A number of prescriptions drugs are found in her purse
serum glucose concentration is 50 mg/dl
which of the following drugs is the most likely cause of the hypoglycemia ?
a.-acarbose
b.-captopril
c.-digoxin
d.-glyburide
e.-methyldopa
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| Leopard
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Glyburide = A hypoglycemic drug because it causes secretion of insulin
Thread Extension
What is its mechanism of Action ???
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| aisha2
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Second generation suflonylureas : Glyburide, Glipizide, Glimepiride
close K+ channels in beta-cell membrane -----> depolarization ------------> increase Ca2+ influx -------> insuline release
i was initaly mixin it up with the Glitazones : pioglitazone & rosigiltazone mech for that is upregulation of insuline receptors at the target organ
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| aisha2
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Acarbose & miglitol are alfa-glucosidase inhibitors, they block absorbtion.
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| aisha2
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methyldopa---------------> alfa-2-receptor blocker and i think they r centrally actin not sure about that 
digoxin----------> Na-K ATPase pump inhibitor
captopril-----------> ACEI
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| Cedrick
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cool
very cool
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| Leopard
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Very nice
Which Drug opens this ATP dependent K channels in Beta cells ??
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| Cedrick
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correct choice
d.-glyburide
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| aisha2
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insuline,??????????
i dont know the answer actually
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| aisha2
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i remember there where 2 drugs that were centrally actin alfa blockers , i think the other one was clonidine........ plz tell me if im wrong
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| Leopard
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Aisha you tried ,that is good point but
Correct answer is DIZOXIDE {which is used primarily as anithypertensive (same action on blood vessels) and also in Insulinomas }
NEXT QUESTION
Which oral diabetic drug which can cause vit B12 deficiency???
Best of luck
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| aisha2
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i think im , ill double check this section , im not so good with pharm anyway,
for the next Q i think it is acarbose(alfa-glucosidase inhibitor) as its the only one workin on the GIT.
plz correct me if im worng
got to run now , have to pick up my son , thankx for all the Qs and answers.
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| aisha2
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correction here , alfa-methyldopa and clonidine are centraly actin alfa2-agonist......... decreasin the central adrenergic outflow
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| aisha2
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THANKX Leopard ,
Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.
It is used as a vasodilator in the treatment of acute hypertension, and also to decrease the secretion of insulin in disease states such as insulinoma (a tumor producing insulin).
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