aisha2
Forum Guru
Topics: 37
Posts: 414
|
Procainamide and hydralazine are most commonly associated with drug-induced lupus. Procainamide is used to treat arrhythmias, and hydralazine is used to treat high blood pressure. Other medicines that can cause drug-induced lupus include:
• chlorpromazine,
• isoniazid, antitubercular
• methyldopa, (high blood pressure)
• quinidine, antiarrhythmic
• anticonvulsants, such as ethosuximide,
• beta-blockers, such as atenolol and propranolol, (high blood pressure)
• captopril, ACE-I (high blood pressure)
• cimetidine,
• penicillamine, Disease-Modifying Antirheumatic drug
• phenazine, an antibiotic
• quinidine, antiarrhythmic
The symptoms of lupus may not appear at low doses . However, as the dose increases, the lupus-like syndrome may appear. Also, use of some of these medicines for long periods of time increases one's risk .
plz feel free to add more
___________________
NEVER GIVE UP IN LIFE, BE PERSISTENT
|
| Leopard
Forum Guru
Topics: 30
Posts: 401
|
Good list .
Thread Extension
INH
procainamide
Hydralazine
These three drugs are most notorious for causing Drug induced Lupus.
What other Characteristic is shared by these three drugs ??
___________________
FA is just a good revision book.It is not a "real" learning tool.
|
| lightray
Forum Newbie
Topics: 1
Posts: 18
|
hey another drug which is reported to induce lupus LOVASTATIN (HMG -CoA reductase inhibitor)
|
| aisha2
Forum Guru
Topics: 37
Posts: 414
|
honestly i have no idea , i looked up every possible thing that came to my mind .......... would like to know the answer
___________________
NEVER GIVE UP IN LIFE, BE PERSISTENT
|
| Leopard
Forum Guru
Topics: 30
Posts: 401
|
This trio of drugs is metabolised by Acetylation so all of them are affected by
slow acetylaters and rapid acetylater (genetic predisposition)
Best of luck
___________________
FA is just a good revision book.It is not a "real" learning tool.
|
| aisha2
Forum Guru
Topics: 37
Posts: 414
|
how would u differentiate b/w acctual SLE & drug induced LE?
___________________
NEVER GIVE UP IN LIFE, BE PERSISTENT
|
| Leopard
Forum Guru
Topics: 30
Posts: 401
|
aisha2 wrote:
how would u differentiate b/w acctual SLE & drug induced LE?
- LAB shows that in Drug induced LE there
- Anti histone antibodies
- No anti dsDNA or anti Sm antibodies
- Complement level normal
- Recovery with discontinuation of drug
- CLINICAL
- Low incidence of renal , skin and CNS involvment
- Sex ratio is equal
Best of luck
___________________
FA is just a good revision book.It is not a "real" learning tool.
|
| docarchana
Forum Guru
Topics: 70
Posts: 515
|
which organ is commonly affected in drug induced SLE... liver?????
|
| Leopard
Forum Guru
Topics: 30
Posts: 401
|
docarchana wrote:
which organ is commonly affected in drug induced SLE... liver?????
Clinical manifestation is is
- Fever
- Myalgia
- Arthralgia /Arthritis
- serositis
- Rash +/-
{Kidney and CNS involvement are not absolute exceptions but their incidence is pretty low}
Best of luck
___________________
FA is just a good revision book.It is not a "real" learning tool.
|
| ing
Forum Guru
Topics: 45
Posts: 435
|
Way to go! Good luck everybody!
___________________
Never give up!!
|
| Cedrick
Forum Fanatic
Topics: 322
Posts: 1,981
|
that is the way
sweet
|
| docarchana
Forum Guru
Topics: 70
Posts: 515
|
i just read that actual SLE usually doesnot involve live.
|
| docarchana
Forum Guru
Topics: 70
Posts: 515
|
typo - liver..
|
| Leopard
Forum Guru
Topics: 30
Posts: 401
|
Below is a copy pasting of "gp notebook"
GI disturbance is not usually a major feature in SLE:
- nausea, vomiting, or anorexia occur in about 20% of cases abdominal pain is uncommon and may suggest infarction or perforation of the large or small bowel ascites is rare but often massive hepatomegaly occurs in about 30% of cases splenomegaly occurs in about 20% of cases and is unusually associated with haemolytic anaemia
The link is
http://www.gpnotebook.com/simplepage.cfm?ID=-1389...
___________________
FA is just a good revision book.It is not a "real" learning tool.
|
| docarchana
Forum Guru
Topics: 70
Posts: 515
|
thanx for the link, leopard..
|
|
| |
| | | | | | | | | | | | | | | |
