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13 Posts

blueocean
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Posts: 195

09/06/06 - 02:21 PM

Two sisters are diagnosed with hemolytic anemia. Their older brother was previously diagnosed with the same disorder. Two other brothers are asymptomatic. The mother and father are second cousins. Deficiency of which of the following enzymes would be most likely to cause this disorder?
A. Debranching enzyme
B. Glucose-6-phosphatase
C. Glucose-6-phosphate dehydrogenase
D. Muscle phosphorylase
E. Pyruvate kinase

Cedrick
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09/06/06 - 02:24 PM

where is the question just a big photo

blueocean
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09/06/06 - 02:34 PM

I made something with my computer and I can not handle it!I dont't know where is the question but I can try again!
shocked

Leopard
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09/06/06 - 03:29 PM

E

Pyruvate Kinase

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docsrinu
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09/06/06 - 07:57 PM

hemolytic anemia - C or E. females affected. so E....

drpkaur
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09/06/06 - 08:54 PM

E for sure...as G6PD IS X-linked...

blueocean
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09/07/06 - 07:58 AM

drakarlis
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09/15/06 - 04:06 PM

My answer is C, because in the question is affected both sex (female and male) not only the girls. The question says:" Their older brother was previously diagnosed with the same disorder".

suv
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09/15/06 - 05:20 PM

only males are affected in an x linked recessive condition i.e., G6PD deficiency
so it is pyruvate kinase deficiency

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verapamil
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04/28/07 - 12:25 PM

#10

again sorry for the old school posts but i think the question is very good..

my answer is g6pd because x-link recessive dses can be passed down to males if the the mother is the carrier.

all the posts are correct in saying that there is no male to male transmission but the question doesn't state that the father has the disease.

grin

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lq2006
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05/23/07 - 11:39 PM

#11

Pyruvate kinase

SmokyWaters
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05/24/07 - 09:00 AM

#12

pyruvate kinase usually comes up with congenital lacticacidosis which usually precipitates after a heavy carbohydrate meal...
truely its the most common glycolytic enzyme deficiency hemolytic anemia cause ...
but the most common enzyme deficiency linked hemolytic anemia is G6PD def anemia...
G6PD def is known as X-linked recessive disease doesnt mean that girls cant have it....
if the father is also carrying a recessive X gene and mother is also carrying an recessive X linked gene....sisters can be HOMOZYGOUS for the disease...
so I wud go for G6PD smiling face

nandrolone
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06/12/07 - 06:27 AM

#13

hi guys

this is kaplan 2007 q bank question............

please dont post such questions and play with our right to self assessment .......................

if you want .......you can lable them before posting

please please

please

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