dr_brown
Forum Newbie
Topics: 1
Posts: 3
|
Heres a little teaser. Yohimbine is readily available on the internet, advertised for men who are having erection troubles.
Imagine the scene. You have your girl round, and just before you start on the steak you have cooked for dinner, you go to the bathroom and pop a couple of pills. Come back in, start drinking red wine, and eating cheese after your dinner. Two hours later you are dead.
What causes this reaction? 
|
| aisha2
Forum Guru
Topics: 37
Posts: 414
|
Yohimbine is a selective competitive alpha2-adrenergic receptor antagonist and is used for treating erectile dysfunction. It is claimed to be an aphrodisiac. It is also used as a weight loss supplement as it increases noradrenaline (norepinephrine) levels.
At high doses, yohimbine is a monoamine oxidase (MAO) inhibitor.Higher doses of oral Yohimbine create numerous side effects such as rapid heart rate, high blood pressure, and overstimulation.
At high doses, yohimbine is a monoamine oxidase (MAO) inhibitor. MAO inhibitors can cause serious adverse effects when taken concomitantly with tyramine-containing foods (e.g., liver, cheeses, red wine) or with over-the-counter (OTC) products containing phenylpropanolamine, such as nasal decongestants and diet aids.
Tyramine is an amino acid which is found in various foods, and is an indirect sympathomimetic that can cause a hypertensive reaction in patients receiving MAOI therapy.
Monoamine oxidase is found in the gastrointestinal tract and inactivates tyramine;
when drugs prevent the catabolism of exogenous tyramine, this amino acid is absorbed and displaces norepinephrine from sympathetic nerve ending and epinephrine from the adrenal glands. If a sufficient amount of pressor amines are released, a patient may experience a severe occipital or temporal headache, diaphoresis, mydriasis, nuchal rigidity, palpitations, and the elevation of both diastolic and systolic blood pressure may ensue
Edited by aisha2 on 09/06/06 - 02:39 PM
___________________
NEVER GIVE UP IN LIFE, BE PERSISTENT
|
| aisha2
Forum Guru
Topics: 37
Posts: 414
|
so im thinkin he might died of a intracranial hemorrhage or cardiac arrest ......... plz tell me if im wrong
___________________
NEVER GIVE UP IN LIFE, BE PERSISTENT
|
| Cedrick
Forum Fanatic
Topics: 320
Posts: 1,928
|
Or just the thought about was to happen that night
|
| Leopard
Forum Guru
Topics: 30
Posts: 401
|
aisha2 wrote:
Yohimbine is a selective competitive alpha2-adrenergic receptor antagonist and is used for treating erectile dysfunction. It is claimed to be an aphrodisiac. It is also used as a weight loss supplement as it increases noradrenaline (norepinephrine) levels.
At high doses, yohimbine is a monoamine oxidase (MAO) inhibitor.Higher doses of oral Yohimbine create numerous side effects such as rapid heart rate, high blood pressure, and overstimulation.
At high doses, yohimbine is a monoamine oxidase (MAO) inhibitor. MAO inhibitors can cause serious adverse effects when taken concomitantly with tyramine-containing foods (e.g., liver, cheeses, red wine) or with over-the-counter (OTC) products containing phenylpropanolamine, such as nasal decongestants and diet aids.
Tyramine is an amino acid which is found in various foods, and is an indirect sympathomimetic that can cause a hypertensive reaction in patients receiving MAOI therapy.
Monoamine oxidase is found in the gastrointestinal tract and inactivates tyramine;
when drugs prevent the catabolism of exogenous tyramine, this amino acid is absorbed and displaces norepinephrine from sympathetic nerve ending and epinephrine from the adrenal glands. If a sufficient amount of pressor amines are released, a patient may experience a severe occipital or temporal headache, diaphoresis, mydriasis, nuchal rigidity, palpitations, and the elevation of both diastolic and systolic blood pressure may ensue
Thanks a great information
___________________
FA is just a good revision book.It is not a "real" learning tool.
|
| docsrinu
Forum Elite
Topics: 26
Posts: 213
|
he might have died due to intracranial hge as a result of hypertensive crisis.
|
| Leopard
Forum Guru
Topics: 30
Posts: 401
|
Thread extension
How tyramine may cause Hypetensive crisis ????????
___________________
FA is just a good revision book.It is not a "real" learning tool.
|
| Nan
Forum Senior
Topics: 12
Posts: 159
|
Tyramine is an amino acid derived from tyrosine; has a sympathomimetic action. A large dietary intake of tyramine can cause the tyramine pressor response which is defined as an increase in systolic blood pressure of 30 mmHg or more. The displacement of noradrenaline from neuronal storage vesicles by tyramine is thought to cause the vasoconstriction, and increased heart rate and blood pressure of the pressor response.
|
| Leopard
Forum Guru
Topics: 30
Posts: 401
|
Nan wrote:
Tyramine is an amino acid derived from tyrosine; has a sympathomimetic action. A large dietary intake of tyramine can cause the tyramine pressor response which is defined as an increase in systolic blood pressure of 30 mmHg or more. The displacement of noradrenaline from neuronal storage vesicles by tyramine is thought to cause the vasoconstriction, and increased heart rate and blood pressure of the pressor response.
Kool !!!!!!!11
Very nice
It is indirect sympathomimetic ,causing release of N-epinephrin
___________________
FA is just a good revision book.It is not a "real" learning tool.
|
|
| |
| | | | | | | | | |
