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drpkaur
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09/05/06 - 08:38 AM

patient develops pain in the epigastric region radiating to the left side of his back. serum amylase levels are elevated and acute pacreatitis is confirmed. on enquiry this person is a non alcoholic, no previous h/o gallstones, no prveious/recent procedures. A lab work up may show which of the following as a cause of his disease?

a. elevated serum ferritin levels
b. elevated cholesterol levels
c. elevated triglyceride levels
d. elevated copper levels
e. elevated glucose levels

tinabg
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09/05/06 - 11:35 AM

C, elevated triglycerides/VLDL cause acute pancreatitis.

fox
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09/05/06 - 01:16 PM

E diabetics are at incresed risk too.......

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Leopard
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09/05/06 - 03:50 PM

Answer for sure is C

Hypertricglyceridemia particularly above 1000 mg/dl as seen in type I hyperlipidemia (hyperchylmicronemia) is a great risk factor for Acute pancreatitis.

Other metabolic disorder which should be remembered along with it is Hypercalcemia.

Best of luck

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tinabg
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09/05/06 - 08:32 PM

Why hypercalcemia?

blueocean
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09/06/06 - 04:26 AM

Metabolic conditions which can cause PA:
- elevated triglyceride levels in the serum
- abnormalities of calcium metabolism (e.g. hyperparathyroidism).
-poorly controlled diabetes mellitus.
Triglyceride levels in excess of 1000 mg/dL are necessary before acute pancreatitis develops. The precise mechanism through which hypertriglyceridemia causes pancreatitis is unknown.
High levels of calcium in serum can cause PA;proposed mechanisms include pancreatic enzyme activation due to elevated levels of calcium.

tinabg
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09/06/06 - 04:34 AM

What a relief! I was confused because I thought that hypertryglyceridemia may cause hypercalcemia, but now it's clear. Thank you!

drpkaur
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09/06/06 - 09:32 AM

yeah guys the correct answer is C..................GOOD GOING dr blueocean....keep it up...

docsrinu
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09/06/06 - 09:10 PM

tinabg, acute pancreatitis actually presents with HYPO calcemia.

Leopard
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09/06/06 - 09:15 PM

#10

docsrinu wrote:
tinabg, acute pancreatitis actually presents with HYPO calcemia.

That is true

Severe Hypercalcemia --------------------> Acute pancreatitis

Acute pancreatitis --------------------> Hypocalcemia (saponification )

Best of luck

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