spherocyte in AIHA

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spherocyte in AIHA

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Lim
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09/03/06 - 01:38 AM

why is spherocyte in AIHA(autoimmune hemolytic anemia)? (*kaplan pathology 181p 2001ed)

spherocytes in Hereditary spherocytosis is a kind of error in production?

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MRMAVERICK
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09/03/06 - 02:55 AM

spherocytes occur in autoimmune hemolytic anemia because of removal of RBC membrane by macrophages-

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Lim
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09/03/06 - 03:29 AM

Thanks,MRMAVERICK.

you mean it's getting smaller?
why not it becomes schistocytes?
i guess RBC membrane is very fragile,so if it's attacked by IgG and C3(AIHA),it can be broken to schistocytes. what do you think?

thanks in advance.
(i know it's not written in the kaplan pathology book. just my thoughts)

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Leopard
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09/03/06 - 08:04 PM

Normally RBC is is a biconcave disc.When small part of membrane is taked off by the macrophages in the spleen then gradually surface /volume ratio is decreases which converts the RBC from biconcave disc to round sphere (microspherocytosis).Schistocytes are produced only when RBCs are mechanically damaged as in

Microangiopathic anemia
Macroangiopathic anemia.

Maximum you can say why not" Bite cells "??

hehehheheheh

Best of luck

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Lim
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09/04/06 - 09:31 AM

in G6PD def, RBC memb is removed by splenic macrophages. -> Bite cell ( Bite cell is rounder than schistocyte.)

hmm i see Leopard. Thank you smiling face

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